反応 #95437

反応方程式

sodium hydride

3,6-dichloropyridazine

4-amino-2,5-dimethylphenol

→

4-(6-chloro-3-pyridazinyloxy)-2,5-dimethylbenzeneamine

溶媒

dimethyl sulfoxide

反応条件

後処理

1. 1
   その他rose to 65° C
2. 2
   ろ過filtered
3. 3
   その他Recrystallization of the filter cake from methanol

実験手順

4.8 g of sodium hydride was added in portions to a stirred solution of 30 g of 3,6-dichloropyridazine and 27.4 g of 4-amino-2,5-dimethylphenol in 300 ml of dimethyl sulfoxide. The temperature of the mixture rose to 65° C. The mixture was then stirred for 18 hours at room temperature, poured over ice water and filtered. Recrystallization of the filter cake from methanol gave 4-(6-chloro-3-pyridazinyloxy)-2,5-dimethylbenzeneamine, as a brown solid (5A), mp: 138°-140° C.

出典