反応 #95436

反応方程式

sodium hydride

1A

4-amino-2-chlorophenol

3,6-dichloropyridazine

hydrochloric acid

→

4-(6-chloro-3-pyridazinyloxy)benzeneamine

溶媒

dimethyl sulfoxide

反応条件

後処理

1. 1
   その他being held at 50° C
2. 2
   抽出was extracted with methylene chloride
3. 3
   洗浄The extract was washed with water
4. 4
   乾燥dried (magnesium sulfate)
5. 5
   その他the solvent was evaporated

実験手順

12 g of sodium hydride was added in portions to a stirred solution of 71.8 g of 1A and 25 g of 3,6-dichloropyridazine in 300 ml of dimethyl sulfoxide, the temperature of the mixture being held at 50° C. The mixture then was stirred for one hour and poured into ice water. The mixture was slightly acidified with dilute hydrochloric acid, and was extracted with methylene chloride. The extract was washed with water, dried (magnesium sulfate) and the solvent was evaporated to give 4-(6-chloro-3-pyridazinyloxy)benzeneamine (1B), as a tan solid, mp: 126°-129° C.

出典