反応 #95381

反応方程式

diethylamine

2,6-bis-(chloroacetyl-amino)-4-methyl-benzo[1,2-d:5,4-d']bisthiazole

→

title compound

2,6-Bis-(diethylamino-acetylamino)-4-methyl-benzo[1,2-d:5,4-d']bisthiazole

溶媒

dioxane

反応条件

後処理

1. 1
   その他Then it was evaporated to dryness in vacuo
2. 2
   その他the residue (12 gm) was chromatographed on a dry 300 gm-silicagel column with benzene/chloroform (1:1) as the mobile phase

実験手順

20 gm of diethylamine were added to 11.5 gm of 2,6-bis-(chloroacetyl-amino)-4-methyl-benzo[1,2-d:5,4-d']bisthiazole in 80 ml of dioxane and the mixture was boiled for 3 hours. Then it was evaporated to dryness in vacuo, and the residue (12 gm) was chromatographed on a dry 300 gm-silicagel column with benzene/chloroform (1:1) as the mobile phase. The title compound was obtained first; 9.0 gm (66% of theory), melting point 191°-192° C., were obtained after recrystallization from alcohol.

出典