反応 #95223

反応方程式

5-amino-3-trichloromethyl-1,2,4-thiadiazole

2,4-dichlorobenzoyl chloride

→

pure product

収率 69.5%

5-(2,4-Dichlorobenzamido)-3-Trichloromethyl-1,2,4-Thiadiazole

収率 69.5%

溶媒

xylene

反応条件

後処理

1. 1
   濃縮The reaction mixture was concentrated in vacuo
2. 2
   抽出the resulting residue extracted with benzene
3. 3
   workup.ADDITIONAddition of hexane

実験手順

A solution of 10.9 g (0.05 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 20.9 g (0.10 mole) 2,4-dichlorobenzoyl chloride was refluxed in 200 ml xylene for 20 hours. The reaction mixture was concentrated in vacuo and the resulting residue extracted with benzene. Addition of hexane resulted in precipitation of 13.6 g (69% yield) pure product; m.p. 136° C.

出典