反応 #95222

反応方程式

5-amino-3-trichloromethyl-1,2,4-thiadiazole

2,6-dichlorobenzoyl chloride

→

pure product

収率 22.0%

5-(2,6-Dichlorobenzamido)-3-Trichloromethyl-1,2,4-Thiadiazole

収率 22.0%

溶媒

dichlorobenzene

反応条件

後処理

1. 1
   ろ過After filtration
2. 2
   その他the crude product precipitated from the filtrate
3. 3
   その他Recrystallization from toluene

実験手順

A solution of 22.0 g (0.1 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 20.1 g (0.1 mole) 2,6-dichlorobenzoyl chloride was refluxed for 8 hours in 200 ml dichlorobenzene. After filtration, the crude product precipitated from the filtrate upon standing. Recrystallization from toluene gave 8.6 g (22% yield) of pure product; m.p. 209° C.

出典