反応 #95220

反応方程式

5-amino-3-trichloromethyl-1,2,4-thiadiazole

2-chlorobenzoyl chloride

→

crude product

収率 85.0%

5-(2-Chlorobenzamido)-3-Trichloromethyl-1,2,4-Thiadiazole

収率 85.0%

溶媒

xylene

反応条件

後処理

1. 1
   濃縮After concentration in vacuo
2. 2
   その他the resulting oil was triturated with cold hexane

実験手順

A solution of 10.9 g (0.05 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 17.5 g (0.10 mole) 2-chlorobenzoyl chloride was heated at reflux for 18 hours in 200 ml xylene. After concentration in vacuo, the resulting oil was triturated with cold hexane to give 14.9 g (85% yield) of crude product. Recrystallization from benzene/hexane gave a pure product; m.p. 142° C.

出典