反応 #95218

反応方程式

5-amino-3-trichloromethyl-1,2,4-thiadiazole

4-nitrobenzoyl chloride

→

pure product

収率 73.5%

5-(4-Nitrobenzamido)-3-Trichloromethyl-1,2,4-Thiadiazole

収率 73.5%

溶媒

toluene

反応条件

後処理

1. 1
   温度at reflux for 20 hours
2. 2
   その他the crude product precipitated from the reaction mixture
3. 3
   その他was isolated by filtration
4. 4
   洗浄After washing with hexane

実験手順

A solution of 10.9 g (0.05 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 10.2 g (0.055 mole) 4-nitrobenzoyl chloride in 200 ml toluene was heated at reflux for 20 hours. Upon cooling to room temperature, the crude product precipitated from the reaction mixture and was isolated by filtration. After washing with hexane, 13.5 g (73% yield) of pure product was obtained; m.p. 214° C.

出典