反応 #95215

反応方程式

5-amino-3-trichloromethyl-1,2,4-thiadiazole

4-toluoyl chloride

→

crude product

5-(4-Toluamido)-3-Trichloromethyl-1,2,4-Thiadiazole

溶媒

toluene

反応条件

後処理

1. 1
   温度at reflux for 20 hours
2. 2
   その他Unreacted amino compound was removed
3. 3
   温度by cooling the reaction mixture
4. 4
   ろ過filtering the precipitate

実験手順

A solution of 11.0 g (0.05 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 8.0 g (0.05 mole) 4-toluoyl chloride in 250 ml toluene was heated at reflux for 20 hours. Unreacted amino compound was removed by cooling the reaction mixture and filtering the precipitate. Concentration of the filtrate in vacuo gave the crude product, which was purified by recrystallization from cyclohexane. Yield was 9.1 g (27%); m.p. 127° C.

出典