反応 #952

反応方程式

benzyl chloroformate

( ii )

4-amidino benzyl azide

triethyl amine

HCl

Benzyl chloroformate

→

4-(benzyloxycarbonylamidino) benzyl azide

溶媒

water

methylene chloride

反応条件

後処理

1. 1
   乾燥the resulting solution was dried (K2CO3)
2. 2
   ろ過filtered
3. 3
   温度was cooled in an ice bath
4. 4
   乾燥The organic phase was dried (MgSO4)
5. 5
   その他the solvent was removed in vacuo

実験手順

The crystals from (ii) above were dissolved in 500 ml methylene chloride and the resulting solution was dried (K2CO3), filtered and 27 ml (194 mmol) triethyl amine was added. 25 ml Benzyl chloroformate was slowly added to the stirred solution while the reaction mixture was cooled in an ice bath. After 30 minutes an additional 2 ml benzyl chloroformate was added and stirring was continued for another 30 minutes. Subsequently, water was added and the aqueous phase was adjusted to pH 7 with 2M HCl. The organic phase was dried (MgSO4) and the solvent was removed in vacuo. 4-(benzyloxycarbonylamidino) benzyl azide was finally isolated as colorless crystals from ether/methylene chloride/hexane.

出典