反応 #95098

反応方程式

4-benzyloxyphenylhydrazine-hydrochloride

(3-chlorophenyl)-acetone

sulfuric acid

→

5-Benzyloxy-3-(3-chloro-phenyl)-2-methyl-1H-indole

溶媒

ethanol

反応条件

後処理

1. 1
   温度was refluxed for five hours
2. 2
   workup.DISTILLATIONAfter the ethanol was distilled off
3. 3
   workup.ADDITIONthe residue was mixed with water
4. 4
   抽出extracted with chloroform
5. 5
   乾燥The extracts were dried over sodium sulfate
6. 6
   その他evaporated
7. 7
   その他The evaporation residue was purified by chromatography on silicagel

実験手順

An amount of 11.7 g (47 m mole) of 4-benzyloxyphenylhydrazine-hydrochloride and 6.39 g (38 m mole) of (3-chlorophenyl)-acetone was dissolved in 35 ml of absolute ethanol, and after addition of 2.7 ml of concentrated sulfuric acid the mixture was refluxed for five hours. After the ethanol was distilled off, the residue was mixed with water and extracted with chloroform. The extracts were dried over sodium sulfate and evaporated. The evaporation residue was purified by chromatography on silicagel by using toluene as solvent.

出典