反応 #95050

反応方程式

Chloroacetonitrile

m-aminobenzotrifluoride

K2CO3

charcoal

→

m-trifluoromethylanilinoacetonitrile

収率 73.7%

溶媒

DMSO

water

反応条件

後処理

1. 1
   その他resulted in the formation of an oil
2. 2
   抽出The mixture was extracted with CH2Cl2
3. 3
   その他the extracts obtained
4. 4
   ろ過filtered

実験手順

Chloroacetonitrile (16 g), m-aminobenzotrifluoride (32.2 g), K2CO3 (39.2 g) and DMSO (40 ml) were heated with stirring in a round-bottomed three-necked flask at 70°-80° C. for 4.0 hours. Pouring the reaction mixture into approximately 1 liter of ice and water resulted in the formation of an oil. The mixture was extracted with CH2Cl2 and the extracts obtained treated with diatomaceous earth and activated charcoal, and then filtered. The filtrate was taken to dryness, which gave 29.5 g of m-trifluoromethylanilinoacetonitrile as a dark oil.

出典