反応 #95013

反応方程式

Sodium hydride

benzyl alcohol

2,3-dichloropyrazine

→

2-chloro-3-benzyloxypyrazine

溶媒

benzene

benzene

反応条件

後処理

1. 1
   温度The mixture is refluxed for 20-60 hours
2. 2
   温度cooled
3. 3
   洗浄washed with water
4. 4
   その他dried
5. 5
   その他evaporated
6. 6
   workup.DISTILLATIONthe product distilled in vacuo

実験手順

Sodium hydride (0.10 mole) is added to 0.10 mole of benzyl alcohol in 100 ml. dry benzene and the mixture is refluxed 1-2 hours. The cooled solution is treated with 0.10 mole of 2,3-dichloropyrazine in 100 ml. of benzene. The mixture is refluxed for 20-60 hours, cooled, washed with water, dried, and evaporated and the product distilled in vacuo to give 2-chloro-3-benzyloxypyrazine.

出典