反応 #95000

反応方程式

trichloroacetamidine

potassium carbonate

ethyl-4-chloroacetoacetate

→

crude product

収率 36.1%

6-Chloromethyl-4-Hydroxy-2-Trichloromethylpyrimidine

収率 36.1%

溶媒

water

反応条件

後処理

1. 1
   ろ過The aqueous solution was filtered
2. 2
   その他to give a precipitate
3. 3
   洗浄The precipitate was washed
4. 4
   その他dried

実験手順

A mixture of 30.0 g (0.18 mole) trichloroacetamidine, 25.2 g (0.18 mole) potassium carbonate, 30.3 g (0.18 mole) ethyl-4-chloroacetoacetate and 400 ml water was stirred 18 hours. The aqueous solution was filtered and acidified with hydrochloric acid to give a precipitate. The precipitate was washed and dried to give 17.0 g (36% yield) of crude product. An analytical sample recrystallized from ligroin had mp 138°-144° C. The structure was confirmed via infrared and elemental analysis.

出典