反応 #94997

反応方程式

4-hydroxy-6-methyl-2-trichloromethylpyrimidine

triethylamine

dimethylthiocarbamoyl chloride

→

product

収率 55.0%

6-Methyl-2-Trichloromethyl-4-Pyrimidinyl Dimethylthiocarbamate

収率 55.0%

溶媒

ether

反応条件

後処理

1. 1
   温度was refluxed 16 hours
2. 2
   ろ過A trace of dark solid was filtered out
3. 3
   その他the solution was evaporated on a steam bath
4. 4
   その他to give a solid residue
5. 5
   抽出This residue was extracted with hot ligroin

実験手順

A mixture of 5.7 g (0.025 mole) 4-hydroxy-6-methyl-2-trichloromethylpyrimidine, 2.6 g (0.025 mole) triethylamine, 3.2 g (0.025 mole) dimethylthiocarbamoyl chloride, and 100 ml ether was refluxed 16 hours. A trace of dark solid was filtered out and the solution was evaporated on a steam bath to give a solid residue. This residue was extracted with hot ligroin to yield 4.3 g (55% yield) of product (mp 81°-83° C.) on cooling. The structure was confirmed via infrared and elemental analysis.

出典