反応 #9491

反応方程式

7-Bromo-4-chloro-3-nitroquinoline

1-(3-aminopropyl)pyrrolidin-2-one

→

1-[3-(7-bromo-3-nitroquinolin-4-ylamino)propyl]pyrrolidin-2-one

収率 84.0%

反応条件

実験手順

7-Bromo-4-chloro-3-nitroquinoline (35.26 g, 123.8 mmol) was treated with 1-(3-aminopropyl)pyrrolidin-2-one (19.1 mL, 136.2 mmol) according to the method described in Part E of Example 1 to provide 40.87 g of 1-[3-(7-bromo-3-nitroquinolin-4-ylamino)propyl]pyrrolidin-2-one as a yellow solid.

出典