反応 #94840

反応方程式

phenyl isothiocyanate

triethylamine

1,3-dimethyl-2-imino-imidazolidine hydrobromide

→

N-(1,3-dimethyl-2-imidazolidinylidene)-N'-phenyl-thiourea

溶媒

chloroform

chloroform

反応条件

後処理

1. 1
   温度the reaction mixture is refluxed for 15 hours
2. 2
   温度After cooling
3. 3
   洗浄it is washed with water
4. 4
   乾燥dried over sodium sulfate
5. 5
   その他evaporated in vacuo

実験手順

30.4 g (0.3 mol) of triethylamine are added to a suspension of 58.2 g (0.3 mol) of 1,3-dimethyl-2-imino-imidazolidine hydrobromide in 470 ml of chloroform, at 5°, with stirring. A solution of 40.6 g (0.3 mol) of phenyl isothiocyanate in 235 ml of chloroform is then added dropwise and the reaction mixture is refluxed for 15 hours. After cooling, it is washed with water, dried over sodium sulfate and evaporated in vacuo. Crude N-(1,3-dimethyl-2-imidazolidinylidene)-N'-phenyl-thiourea is obtained and after recrystallisation from ethanol this melts at 195°-196°.

出典