反応 #94827

反応方程式

21-Chloro-21-(phenylsulfinyl)pregna-4,9(11),17(20),20-tetraen-3-one

THF

Sodium methoxide

→

title compound

21-Chloro-20-methoxy-21-(phenylsulfinyl)pregna-4,9(11),17(20)-trien-3-one

溶媒

methanol

反応条件

後処理

1. 1
   温度cooled to 0°-5° under nitrogen
2. 2
   workup.STIRRINGThe mixture is stirred 1 hr
3. 3
   その他quenched with water (10 ml)
4. 4
   抽出The mixture is extracted with ethyl acetate (2×15 ml)
5. 5
   乾燥dried over sodium sulfate
6. 6
   濃縮concentrated under reduced pressure

実験手順

21-Chloro-21-(phenylsulfinyl)pregna-4,9(11),17(20),20-tetraen-3-one, (V, Example 2, 100 mg) and THF (1 ml) are slurried and cooled to 0°-5° under nitrogen. Sodium methoxide in methanol (25%, 0.05 ml) is added with stirring. The mixture is stirred 1 hr and then quenched with water (10 ml). The mixture is extracted with ethyl acetate (2×15 ml). The organic extracts are combined, backwashed with water (10 ml), dried over sodium sulfate and concentrated under reduced pressure to give the title compound.

出典