反応 #948

反応方程式

2-amino-2-ethyl-1,3-propanediol

diethyl carbonate

EtOH

→

desired product

(+-)-Ethyl-4-(hydroxymethyl)-2-oxazolidinone

反応条件

後処理

1. 1
   その他was collected
2. 2
   温度The reaction mixture was cooled
3. 3
   workup.ADDITIONadded acetone (200 ml)
4. 4
   その他to stand overnite at room temperature
5. 5
   ろ過The resulting suspension was filtered

実験手順

Sodium methoxide (2.2 g, Aldrich) was added to a solution of 2-amino-2-ethyl-1,3-propanediol (100.0 g, Aldrich) and diethyl carbonate (169.0 g, Aldrich) This solution was refluxed in a Dean Stark apparatus until no more EtOH was collected. The reaction mixture was cooled, added acetone (200 ml) and allowed to stand overnite at room temperature. The resulting suspension was filtered to give 81.0 g of the desired product as a beige solid. 1H NMR consistent with the proposed structure.

出典