反応 #9476

反応方程式

1-(3-amino-7-bromoquinolin-4-ylamino)-2-methylpropan-2-ol

Ethoxyacetyl chloride

→

N-[7-bromo-4-(2-hydroxy-2-methylpropylamino)quinolin-3-yl]-2-ethoxyacetamide

溶媒

dichloromethane

反応条件

後処理

1. 1
   その他A precipitate formed
2. 2
   その他was isolated by filtration

実験手順

A solution of 1-(3-amino-7-bromoquinolin-4-ylamino)-2-methylpropan-2-ol (158.19 g, 0.510 mol) in dichloromethane (1.2 L) was cooled to 0° C. Ethoxyacetyl chloride (62.50 g, 0.510 mol) was added dropwise, and then the reaction was allowed to warm to ambient temperature and stirred overnight. A precipitate formed and was isolated by filtration to provide N-[7-bromo-4-(2-hydroxy-2-methylpropylamino)quinolin-3-yl]-2-ethoxyacetamide as a solid.

出典