反応 #9475

反応方程式

1-(7-bromo-3-nitroquinolin-4-ylamino)-2-methylpropan-2-ol

→

1-(3-amino-7-bromoquinolin-4-ylamino)-2-methylpropan-2-ol

収率 85.7%

溶媒

acetonitrile

反応条件

後処理

1. 1
   その他for two days
2. 2
   ろ過The reaction mixture was filtered through a layer of CELITE
3. 3
   ろ過filter aid
4. 4
   洗浄the filter cake was washed with ethanol (1 L)
5. 5
   濃縮The filtrate was concentrated under reduced pressure

実験手順

A solution of 1-(7-bromo-3-nitroquinolin-4-ylamino)-2-methylpropan-2-ol (27.78 g, 81.66 mmol) in acetonitrile (1.2 L) was added to a Parr vessel charged with 5% platinum on carbon (0.84 g), and the reaction was placed under hydrogen pressure (50 psi, 3.4×105 Pa) for two days. The reaction mixture was filtered through a layer of CELITE filter aid, and the filter cake was washed with ethanol (1 L). The filtrate was concentrated under reduced pressure to provide 21.70 g of 1-(3-amino-7-bromoquinolin-4-ylamino)-2-methylpropan-2-ol as a yellow oil.

出典