反応 #9474

反応方程式

Triethylamine

7-bromo-4-chloro-3-nitroquinoline

1-Amino-2-methylpropan-2-ol

→

1-(7-bromo-3-nitroquinolin-4-ylamino)-2-methylpropan-2-ol

収率 78.5%

溶媒

dichloromethane

反応条件

後処理

1. 1
   温度to warm to ambient temperature
2. 2
   その他A precipitate formed
3. 3
   その他was isolated by filtration
4. 4
   洗浄washed with water
5. 5
   その他The crude solid was recrystallized from a mixture of isopropanol and acetonitrile

実験手順

Triethylamine (17.35 mL, 124 mmol) was added to a solution of 7-bromo-4-chloro-3-nitroquinoline (29.84 g, 104 mmol) in dichloromethane (253 mL), and the reaction was cooled to 0° C. 1-Amino-2-methylpropan-2-ol (10.17 g, 114 mmol) was added dropwise, and then the reaction was allowed to warm to ambient temperature and stirred overnight. A precipitate formed and was isolated by filtration and washed with water. The crude solid was recrystallized from a mixture of isopropanol and acetonitrile to provide 27.78 g of 1-(7-bromo-3-nitroquinolin-4-ylamino)-2-methylpropan-2-ol as a solid.

出典