反応 #94691

反応方程式

ethyl mercaptoacetate

4-chloro-1-(2-furyl)-1-butanol

sodium ethoxide

→

4-(carbethoxymethylthio)-1-(2-furyl)-1-butanol

溶媒

ethanol

反応条件

後処理

1. 1
   温度To a stirred, refluxing
2. 2
   温度at reflux for 3 hours
3. 3
   温度cooled
4. 4
   濃縮concentrated
5. 5
   その他to remove most of the ethanol
6. 6
   その他The residue is partitioned with ether and water
7. 7
   洗浄The ether phase is washed with brine
8. 8
   乾燥dried over potassium carbonate
9. 9
   濃縮The solution is concentrated
10. 10
    workup.ADDITIONdiluted with xylene
11. 11
    その他to give an oil

実験手順

To a stirred, refluxing mixture of ethyl mercaptoacetate, and 4-chloro-1-(2-furyl)-1-butanol (Example 160), and sodium ethoxide in ethanol. The resulting mixture is stirred at reflux for 3 hours, cooled, and concentrated to remove most of the ethanol. The residue is partitioned with ether and water. The ether phase is washed with brine and dried over potassium carbonate. The solution is concentrated, diluted with xylene, and again conentrated to give an oil.

出典