反応 #9467

反応方程式

8-Bromo-1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine

benzeneboronic acid

→

1-isobutyl-8-phenyl-1H-imidazo[4,5-c]quinolin-4-amine

反応条件

後処理

1. 1
   その他Recrystallization from isopropanol
2. 2
   その他followed by recrystallization from methanol

実験手順

8-Bromo-1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine and benzeneboronic acid were coupled according to the general procedure described in Part J of Example 1. Recrystallization from isopropanol followed by recrystallization from methanol afforded 1-isobutyl-8-phenyl-1H-imidazo[4,5-c]quinolin-4-amine as a beige solid, m.p. 203–204° C.

出典