反応 #9466

反応方程式

8-Bromo-1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine

pyridine-3-boronic acid

→

1-isobutyl-8-(pyridin-3-yl)-1H-imidazo[4,5-c]quinolin-4-amine

反応条件

後処理

1. 1
   その他Purification by chromatography on silica gel (7%–10% methanol in CH2Cl2 gradient)

実験手順

8-Bromo-1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine and pyridine-3-boronic acid were coupled according to the general procedure described in Part J of Example 1. Purification by chromatography on silica gel (7%–10% methanol in CH2Cl2 gradient) afforded 1-isobutyl-8-(pyridin-3-yl)-1H-imidazo[4,5-c]quinolin-4-amine as a white solid, m.p. 244–246° C.

出典