反応 #9458

反応方程式

phosphorous oxychloride

3-nitro-7-phenylquinolin-4-ol

→

4-chloro-3-nitro-7-phenylquinoline

溶媒

N,N-dimethylformamide

DMF

反応条件

後処理

1. 1
   workup.ADDITIONpoured into 250 mL
2. 2
   その他crushed ice
3. 3
   ろ過The resulting precipitate was collected by filtration
4. 4
   洗浄washed with H2O
5. 5
   その他dried under vacuum for 2 h

実験手順

A solution of phosphorous oxychloride (3.1 g, 20 mmol) in anhydrous N,N-dimethylformamide (DMF, 14 mL) was added to a suspension of 3-nitro-7-phenylquinolin-4-ol (5.0 g, 18.8 mmol) in 80 mL of DMF over 3 min. The reaction was allowed to stir for 1.5 h and then poured into 250 mL crushed ice. The resulting precipitate was collected by filtration, washed with H2O, and dried under vacuum for 2 h. The crude 4-chloro-3-nitro-7-phenylquinoline thus obtained was used without further purification.

出典