反応 #94546

反応方程式

Tri-n-butyl phosphine

2-chloropropanoic acid

phosphine

→

Tri-n-butyl(1-carboxyethyl)phosphonium Chloride

溶媒

acetone

反応条件

後処理

1. 1
   温度was maintained at a rate such that the temperature
2. 2
   その他did not exceed about 35° C
3. 3
   workup.ADDITIONAfter the addition
4. 4
   その他the acetone solvent was removed under reduced pressure
5. 5
   その他leaving a viscous liquid

実験手順

Tri-n-butyl phosphine (20.27 g, 25 ml, 0.1 mole) was added dropwise to a rapidly stirred solution of 2-chloropropanoic acid (10.85 g, 9.1 ml, 0.1 mole) in 31 ml of acetone. The reaction was, of course, exothermic, and the addition of the phosphine was maintained at a rate such that the temperature did not exceed about 35° C. After the addition was complete, the acetone solvent was removed under reduced pressure leaving a viscous liquid having an infrared spectrum and elemental analysis corresponding to the formula ##STR13##

出典