反応 #945

反応方程式

benzaldehyde

product

Ethyl 2-aminobutyrate hydrochloride

magnesium sulphate

triethylamine

→

desired product

収率 88.9%

Ethyl 2-benzylideneaminobutyrate

収率 88.9%

溶媒

dichloromethane

反応条件

後処理

1. 1
   ろ過then filtered
2. 2
   濃縮The filtrate was concentrated
3. 3
   その他triturated in diethyl ether
4. 4
   ろ過filtered
5. 5
   濃縮concentrated

実験手順

A solution of the product from step (a) (149.6 g), magnesium sulphate (74.3 g), and triethylamine (246 ml) in dichloromethane (1500 ml) was stirred at room temperature under nitrogen and benzaldehyde (94.9 g, Aldrich) was added dropwise. The mixture was stirred at room temperature for 3 hours then filtered. The filtrate was concentrated, triturated in diethyl ether, filtered and concentrated to yield the desired product as a yellow oil (174 g). 1H NMR consistent with the proposed structure.

出典