反応 #943989

反応方程式

water

7-hydroxy-6-methoxy-1-tetralone

benzyl bromide

K2CO3

→

product

収率 62.8%

7-Benzyloxy-6-methoxy-3,4-dihydro-2H-naphthalen-1-one

収率 62.8%

溶媒

acetone

反応条件

後処理

1. 1
   温度was heated
2. 2
   温度to reflux overnight
3. 3
   その他The reaction
4. 4
   温度as cooled
5. 5
   抽出extracted with EtOAc
6. 6
   乾燥The EtOAc was dried over Na2SO4
7. 7
   その他evaporated
8. 8
   その他to give 7 g of crude product
9. 9
   その他Crystallization with Et2O

実験手順

A mixture of 4.5 g (0.0233 mole) of 7-hydroxy-6-methoxy-1-tetralone, 5.4 g (0.032 mole) of benzyl bromide and 10 g (0.072 mole) of K2CO3 in 150 ml of acetone was heated to reflux overnight. The reaction as cooled, poured into water and extracted with EtOAc. The EtOAc was dried over Na2SO4 and evaporated to give 7 g of crude product. Crystallization with Et2O gave 4.13 g of product as a white solid, mp 110-111° C.

出典