反応 #94294

反応方程式

2-(4-methoxyphenyl)imidazo[1,2-a]pyridine

methyl iodide

methyl iodide

→

1-methyl-2-(4-methoxyphenyl)imidazo[1,2-a]pyridinium iodide

溶媒

acetonitrile

反応条件

後処理

1. 1
   温度refluxed for 3 hrs
2. 2
   温度reflux
3. 3
   その他The solids which precipitate
4. 4
   温度on cooling
5. 5
   ろ過are filtered
6. 6
   workup.DISSOLUTIONpartially dissolved
7. 7
   ろ過filtered
8. 8
   温度The isopropanol filtrate is cooled
9. 9
   workup.ADDITIONtreated with diethyl ether
10. 10
    ろ過The crystallized product is filtered
11. 11
    その他dried
12. 12
    その他to give 1.03 g

実験手順

To 2.23 g. of 2-(4-methoxyphenyl)imidazo[1,2-a]pyridine in 50 ml. of acetonitrile is added 2.84 g. of methyl iodide, and the resulting reaction mixture refluxed for 3 hrs. Additional methyl iodide (2 ml.) is added and reflux continued for one hour. The solids which precipitate on cooling are filtered and partially dissolved in boiling isopropanol and filtered. The isopropanol filtrate is cooled and treated with diethyl ether. The crystallized product is filtered and dried to give 1.03 g., m.p. 194-196° C.

出典