反応 #94212

反応方程式

n-propylamine

triethylamine

5-chloro-6-chlorosulfonyl-1-indanone

→

5-Chloro-6-n-propylsulfamoyl-1-indanone

溶媒

acetone

acetone

反応条件

後処理

1. 1
   workup.WAITfor 1 hour at boiling
2. 2
   濃縮The solution is largely concentrated
3. 3
   workup.ADDITION200 ml of water are added
4. 4
   ろ過The precipitate is filtered off with suction
5. 5
   洗浄washed with water

実験手順

A solution of 1.95 g (33 mmoles) of n-propylamine and 3.04 g (30 mmoles) of triethylamine in 50 ml of acetone is added to a solution of 7.95 g (30 mmoles) of 5-chloro-6-chlorosulfonyl-1-indanone in 50 ml of acetone, and the whole is stirred for 6 hours at room temperature, thereafter for 1 hour at boiling temperature. The solution is largely concentrated, 200 ml of water are added, and the mixture is then acidified with 2N hydrochloric acid to a pH of 2. The precipitate is filtered off with suction and washed with water. The product melts at 122° to 123° C.

出典