反応 #9410

反応方程式

oxime

3-fluoro-5-bromobenzaldehyde oxime

→

3-fluoro-5-bromobenzonitrile

収率 89.3%

溶媒

acetonitrile

反応条件

後処理

1. 1
   温度heated
2. 2
   温度under reflux
3. 3
   その他the mixture was evaporated
4. 4
   洗浄washed with sulfuric acid (1N), water, brine
5. 5
   乾燥dried (MgSO4)
6. 6
   その他evaporated

実験手順

The above oxime (3.76 g, 17.24 mmol) and copper (II) acetate (370 mg) were dissolved in acetonitrile (100 cm3) under nitrogen and heated under reflux. After 5 h, the mixture was evaporated, the residue taken into EtOAc, washed with sulfuric acid (1N), water, brine, dried (MgSO4) and evaporated to give 3-fluoro-5-bromobenzonitrile (3.08 g, 15.39 mmol, 89%) which was used without further purification.

出典