反応 #94022

反応方程式

2-chloroethylamine hydrochloride

potassium tert-butoxide

5-(dimethylamino)methyl-2-furanmethanol

→

2-[[5-(dimethylamino)methyl-2-furanyl]methoxy]ethanamine

溶媒

dimethylformamide

反応条件

後処理

1. 1
   その他After 2 hr solvent was removed
2. 2
   抽出the residue basified and extracted with ethyl acetate
3. 3
   その他The residue after removal of solvent
4. 4
   workup.ADDITIONwas treated in ethanol with ethanolic oxalic acid
5. 5
   その他The crystalline salt was recrystallised from ethanol

実験手順

A solution of 2-chloroethylamine hydrochloride (6.25 g) in dry dimethylformamide was added dropwise to a stirred, cooled solution of potassium tert-butoxide (8.96 g) and 5-(dimethylamino)methyl-2-furanmethanol (12.4 g) in the same solvent. After 2 hr solvent was removed, the residue basified and extracted with ethyl acetate. The residue after removal of solvent was treated in ethanol with ethanolic oxalic acid. The crystalline salt was recrystallised from ethanol to give 2-[[5-(dimethylamino)methyl-2-furanyl]methoxy]ethanamine, bis oxalate, m.p. 130°-133° (3.05 g).

出典