反応 #93918

反応方程式

acetic acid

ethyl 8-(2-chloroethylthio)-12-acetoxyheptadecanoate

hydrogen peroxide

water

→

title compound

8-vinylsulfonyl-12-hydroxyheptadecanoic acid

溶媒

ether

反応条件

後処理

1. 1
   workup.ADDITIONThe solution is diluted with 600 ml
2. 2
   洗浄washed with dilute sodium bicarbonate solution and four portions of water
3. 3
   乾燥dried over sodium sulfate
4. 4
   その他Evaporation of the ether in vacuo

実験手順

A solution of ethyl 8-(2-chloroethylthio)-12-acetoxyheptadecanoate (45.1 g., 0.1 mole) and 30% aqueous hydrogen peroxide (50 ml.) in acetic acid (225 ml.) is allowed to stand 20 hours at 25° C. The solution is diluted with 600 ml. of water. The oily product is taken up in ether, washed with dilute sodium bicarbonate solution and four portions of water and dried over sodium sulfate. Evaporation of the ether in vacuo leaves the title compound as a light yellow viscous oil.

出典