反応 #939023

反応方程式

benzimidazole

2-chloroethyl methyl ether

potassium carbonate

→

1-(2-methoxyethyl)-1H-benzimidazole

収率 87.5%

溶媒

N,N-dimethylformamide

反応条件

後処理

1. 1
   温度was heated
2. 2
   workup.DISTILLATIONThe reaction mixture was subjected to conventional aqueous work-up and distillation under reduced pressure for purification

実験手順

In a nitrogen atmosphere, a mixture of 118 g of benzimidazole, 94.5 g of 2-chloroethyl methyl ether, 138 g of potassium carbonate, and 400 g of N,N-dimethylformamide was heated and stirred at 100° C. for 20 hours. The reaction mixture was subjected to conventional aqueous work-up and distillation under reduced pressure for purification, to give 154 g of 1-(2-methoxyethyl)-1H-benzimidazole (boiling point 125° C./33 Pa, yield 87%).

出典