反応 #939021

反応方程式

1,2,3-propanetricarboxylic acid

cyclohexanol

→

1,2,3-propanetricarboxylic acid tricyclohexyl ester

収率 83.4%

溶媒

heptane

toluene

反応条件

後処理

1. 1
   温度was refluxed for 2 days
2. 2
   その他water removed from the reaction mixture
3. 3
   その他After reaction
4. 4
   その他solvent was removed in vacuuo
5. 5
   その他to yield a viscous oil

実験手順

A mixture of 1,2,3-propanetricarboxylic acid (25 g), cyclohexanol (55 g), and p-toluenesulfonic acid (100 mg) in toluene (500 mL) was refluxed for 2 days and water removed from the reaction mixture. After reaction was complete, solvent was removed in vacuuo to yield a viscous oil. The crude material was redissolved in heptane and passed through a pad of silica gel to obtain 1,2,3-propanetricarboxylic acid tricyclohexyl ester (50 g) as a pale yellow oil.

出典