反応 #939018

反応方程式

sulfuric acid

butyl iodide

iodine

adipic acid monoethyl ester chloride

→

Ethyl 6-Oxodecanoate

溶媒

water

toluene

butyl acetate

反応条件

後処理

1. 1
   その他to react
2. 2
   workup.ADDITIONwas added to the reaction solution
3. 3
   抽出The oily layer was extracted with ether
4. 4
   洗浄washed with aqueous sodium hydrogencarbonate
5. 5
   洗浄washed with water
6. 6
   その他dried
7. 7
   その他The residue was evaporated
8. 8
   その他to remove the solvent
9. 9
   workup.DISTILLATIONdistilled

実験手順

A mixture of activated zinc-copper catalyst (11.5 g), butyl acetate (4 g), toluene (5 g), butyl iodide (15 g) and iodine (3 mg) was heated at 110-120° C. for 2 hours. The mixture was then added dropwise with adipic acid monoethyl ester chloride(15.7 g) at 0° C., and then was allowed to react. After the reaction was completed, ice-cooled water was added to the reaction solution, and then decomposed with dilute sulfuric acid. The oily layer was extracted with ether, washed with aqueous sodium hydrogencarbonate, washed with water, and then dried. The residue was evaporated to remove the solvent, and then distilled, thereby giving ethyl 6-oxodecanoate (8.1 g).

出典