反応 #93732

反応方程式

2,6-dimethylphenol

tetrafluoroisophthalonitrile

potassium fluoride

→

desired compound

収率 77.0%

2,4,5-trifluoro-6-(2,6-xylyloxy)isophthalonitrile

収率 77.0%

溶媒

acetone

cyclohexane

acetonitrile

反応条件

後処理

1. 1
   その他the undissolved potassium fluoride was separated by filtration
2. 2
   濃縮The filtrate was concentrated to dryness in vacuo

実験手順

A solution of 1.2 g (10×10-3 mol) of 2,6-dimethylphenol in 40 ml of acetonitrile was dropwise added at a temperature of -10° C. to a solution of 2.0 g (10×10-3 mol) of tetrafluoroisophthalonitrile and 2.9 g (50×10-3 mol) of potassium fluoride. The mixture was allowed to stand at a temperature of -10° C. to 0° C. for 1 hour while stirring and the undissolved potassium fluoride was separated by filtration. The filtrate was concentrated to dryness in vacuo. The resultant residue was dissolved in a mixed solvent of acetone and cyclohexane and 2.3 g (77% yield) of the desired compound No. 37 was obtained as white crystal.

出典