反応 #93731

反応方程式

tetrafluoroisophthalonitrile

methanol

→

2,4,5-Trifluoro-6-methoxyisophthalonitrile

反応条件

後処理

1. 1
   workup.DISTILLATIONThe methanol was distilled off in vacuo to approximately one-fifth volume and ice water
2. 2
   workup.ADDITIONwas then poured to the resultant mixture
3. 3
   ろ過The precipitated crystal was collected by filtration
4. 4
   洗浄was then washed with water
5. 5
   乾燥After drying in vacuo, 1.6 g of the desired compound No
6. 6
   その他20 was obtained

実験手順

A 2.0 g amount of tetrafluoroisophthalonitrile was heated under reflux in 40 ml of methanol for 4 hours. The methanol was distilled off in vacuo to approximately one-fifth volume and ice water was then poured to the resultant mixture. The precipitated crystal was collected by filtration and was then washed with water and a small amount of cold methanol. After drying in vacuo, 1.6 g of the desired compound No. 20 was obtained.

出典