反応 #93698

反応方程式

n-octylamine

hydroquinone

acrylic acid

NaOH

→

N-n-octyl-β-alanine

収率 78.0%

溶媒

methanol

acetone

反応条件

後処理

1. 1
   workup.ADDITIONwas added dropwise
2. 2
   温度while cooling with ice
3. 3
   workup.ADDITIONAfter addition
4. 4
   温度the mixture was refluxed
5. 5
   温度while heating for 4 hours
6. 6
   ろ過filtration
7. 7
   その他drying

実験手順

To a mixture of n-octylamine (516 g, 4.0 mols), hydroquinone (200 mg) and methanol (400 ml), acrylic acid (144 g, 2.0 mols) was added dropwise with stirring while cooling with ice. After addition, the mixture was refluxed while heating for 4 hours. After cooled to room temperature, NaOH (80 g, 2.0 mols) was added. The reaction mixture was despersed in 6 liters of acetone, and filtration and drying were carried out to obtain the Na salt of N-n-octyl-β-alanine as white crystals having a melting point (dec.) of 242° C. (349 g Yield: 78%).

出典