反応 #936858

反応方程式

ammonium chloride

ethyl magnesium bromide

ether

methyl 2-butynoate

ether

→

title compound

4-Ethylhex-2-yn-4-ol

反応条件

後処理

1. 1
   温度The mixture was then cooled to 0°
2. 2
   抽出was extracted into ether

実験手順

A solution of methyl 2-butynoate (1.5 g) in ether (50 ml) was cooled to 0°, treated with ethyl magnesium bromide (21 ml of a 3M solution in ether) and stirred at room temperature for 4 hours. The mixture was then cooled to 0° and treated with saturated ammonium chloride solution, whereafter the product was extracted into ether and the title compound (1.2 g) was isolated by chromatography. IR (CCl4) νmax 2200 (C≡C), 3450 cm-1 (OH); NMR (CCl4) δ1.83 (s, H3C--C≡), 2.3 (s), 1.36-1.6 (m, CH2CH3), 0.93 t, CH3CH2).

出典