反応 #93678

ord-9c4bb4e21d134267b17ad23616663b7f

反応方程式

CC(O)CNCCNc1ccc(NCCNCC(C)O)c2c1C(=O)c1c(O)ccc(O)c1C2=O
1,4-bis[2-(2- hydroxypropylamino)ethylamino]-5,8-dihydroxyanthraquinone
CC(O)C(=O)O
DL-lactic acid
CCO
ethanol
→
CC(O)C(=O)O.CC(O)C(=O)O.CC(O)CNCCNc1ccc(NCCNCC(C)O)c2c1C(=O)c1c(O)ccc(O)c1C2=O
title compound
CC(O)C(=O)O.CC(O)C(=O)O.CC(O)CNCCNc1ccc(NCCNCC(C)O)c2c1C(=O)c1c(O)ccc(O)c1C2=O
1,4-Bis[2-(2-hydroxypropylamino)ethylamino]-5,8-dihydroxyanthraquinone dilactate salt

反応物

CC(O)CNCCNc1ccc(NCCNCC(C)O)c2c1C(=O)c1c(O)ccc(O)c1C2=O
1,4-bis[2-(2- hydroxypropylamino)ethylamino]-5,8-dihydroxyanthraquinone
CC(O)C(=O)O
DL-lactic acid
CCO
ethanol

試薬

なし

溶媒

CC(C)=O
acetone

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    workup.ADDITIONA mixture of 228 mg
  2. 2
    温度cooled
  3. 3
    workup.ADDITIONtreated with 50 ml

実験手順

A mixture of 228 mg. of 1,4-bis[2-(2- hydroxypropylamino)ethylamino]-5,8-dihydroxyanthraquinone, 120 mg. of 80% DL-lactic acid, and 10 ml. of ethanol is heated on a steam bath for 10 minutes, cooled, treated with 50 ml. of acetone and cooled to obtain the title compound.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US04614618uspto-grants-1986_09