反応 #9367

反応方程式

2-(2-Bromo-cyclopent-2-enyl)-N,N-dimethyl-acetamide

lithium triethylborohydride

→

2-(2-bromo-cyclopent-2-enyl)-ethanol

収率 58.0%

溶媒

THF

反応条件

後処理

1. 1
   workup.ADDITIONThe mixture was treated with an aqueous work-up
2. 2
   その他the resultant alcohol was purified by column chromatography

実験手順

2-(2-Bromo-cyclopent-2-enyl)-N,N-dimethyl-acetamide (Intermediate FOUR1) (1.93 g, 8.3 mmol) in THF (50 mL) was reacted with lithium triethylborohydride (19 mL, 1 M in THF) at 0° C. for 1 h. The mixture was treated with an aqueous work-up and the resultant alcohol was purified by column chromatography to give 0.92 g of 2-(2-bromo-cyclopent-2-enyl)-ethanol Intermediate FIVE1.

出典