反応 #9366

反応方程式

2-Bromo-cyclopent-2-enol

2-bromo-cyclopent-2-enol

Intermediate D3

2-bromo-cyclopent-2-enol

N,N-dimethylacetamide dimethyl acetal

→

2-(2-bromo-cyclopent-2-enyl)-N,N-dimethyl-acetamide

収率 63.0%

溶媒

m-xylene

反応条件

後処理

1. 1
   その他the residue was purified on a column of silica gel with 30% to 50% EtOAc

実験手順

2-Bromo-cyclopent-2-enol (Intermediate D3) (2.18 g, 13.4 mmol) and N,N-dimethylacetamide dimethyl acetal (3.5 mL, 21.5 mmol) in m-xylene (˜20 mL) were heated to 140° C. for 14 h. The mixture was freed of solvent and the residue was purified on a column of silica gel with 30% to 50% EtOAc:hexanes to give 2-(2-bromo-cyclopent-2-enyl)-N,N-dimethyl-acetamide (Intermediate FOUR1) 1.95 g (63%) as a brown oil.

出典