反応 #93445

反応方程式

mesityl oxide

2,6 di-tert-butyl-4-mercaptophenol

triethylamine

→

4-Methyl-4-(3,5-di-tert-butyl-4-hydroxyphenylthio)-2-pentanone

溶媒

toluene

toluene

反応条件

後処理

1. 1
   温度The mixture is heated at 50°-55° C. for six hours
2. 2
   その他retained at 60°-65° C.
3. 3
   その他purified by flash chromatography
4. 4
   その他The product is isolated from solution
5. 5
   workup.DISTILLATIONby distilling off the volatiles under vacuum to a final pressure of 0.10 mm. Hg for five hours

実験手順

8.48 Grams of mesityl oxide (0.084 moles) is added dropwise to a solution of 21.0 grams of 2,6 di-tert-butyl-4-mercaptophenol (0.088 moles) and one gram of triethylamine in 30 ml of toluene. The mixture is heated at 50°-55° C. for six hours. The solvent is then stripped off under vacuum and the residue retained at 60°-65° C. and 0.20 mm. Hg. for two hours. The residue is dissolved in toluene and purified by flash chromatography using silica gel. The product is isolated from solution by distilling off the volatiles under vacuum to a final pressure of 0.10 mm. Hg for five hours.

出典