反応 #93370

反応方程式

alpha-isopropyl-alpha-[2-[N-[3-(2-methoxyphenoxy)propyl]amino]ethyl]-3,4,5-trimethoxyphenylacetonitrile

formalin

formic acid

potassium carbonate

→

desired compound

Alpha-isopropyl-alpha-[2-[N-[3-(2-methoxyphenoxy)propyl]-N-methylamino]ethyl]-3,4,5-trimethoxyphenylacetonitrile

溶媒

water

反応条件

後処理

1. 1
   温度was refluxed for 1 hour
2. 2
   温度After cooling, to the mixture
3. 3
   抽出The solution was extracted with chloroform
4. 4
   洗浄The extract was washed with water
5. 5
   その他dried
6. 6
   その他evaporated

実験手順

A mixture of 0.39 g of alpha-isopropyl-alpha-[2-[N-[3-(2-methoxyphenoxy)propyl]amino]ethyl]-3,4,5-trimethoxyphenylacetonitrile, 1 ml of 37% formalin, and 1 ml of 90% formic acid was refluxed for 1 hour. After cooling, to the mixture were added water and potassium carbonate to make it alkaline. The solution was extracted with chloroform. The extract was washed with water, dried, and evaporated to give 0.23 g of desired compound as a yellow oil.

出典