反応 #93367

反応方程式

2-methylbenzimidazole

triethylamine

4-(4-ethoxyphenoxy)benzyl chloride

→

1-[4-(4-ethoxyphenoxy)benzyl]-2-methylbenzimidazole

収率 88.1%

溶媒

toluene

反応条件

後処理

1. 1
   温度was heated
2. 2
   温度under reflux for 5 hours
3. 3
   洗浄The resultant mixture was washed with water
4. 4
   乾燥dried over anhydrous sodium sulfate
5. 5
   workup.DISTILLATIONdistilled under reduced pressure
6. 6
   その他to remove toluene
7. 7
   その他The residue was purified by silica gel column chromatography

実験手順

A mixture of toluene (20 ml), 2-methylbenzimidazole (0.55 g, 4.2 mmole), triethylamine (0.42 g, 4.2 mmole) and 4-(4-ethoxyphenoxy)benzyl chloride (1.00 g, 3.8 mmole) was heated under reflux for 5 hours and then cooled to room temperature. The resultant mixture was washed with water, dried over anhydrous sodium sulfate and distilled under reduced pressure to remove toluene. The residue was purified by silica gel column chromatography to give 1-[4-(4-ethoxyphenoxy)benzyl]-2-methylbenzimidazole (1.20 g) as colorless liquid. nD26.0 1.5984.

出典