反応 #93310

反応方程式

ethoxycarbonylacetylchloride

2-amino-4-(4-methoxyphenyl)-5-(3-pyridyl)-1,3-thiazole

sodium hydrogen chloride

→

2-ethoxycarbonylacetylamino-4-(4-methoxyphenyl)-5-(3-pyridyl)-1,3-thiazole

収率 61.0%

溶媒

dimethylformamide

反応条件

後処理

1. 1
   workup.ADDITIONTo the solution was added under ice-
2. 2
   抽出The resultant was subjected to extraction with ethyl acetate
3. 3
   洗浄The organic layer was washed with water
4. 4
   その他dried
5. 5
   濃縮concentrated
6. 6
   その他followed by recrystallization from tetrahydrofuran

実験手順

In 5 ml of dimethylformamide was dissolved 1 g of 2-amino-4-(4-methoxyphenyl)-5-(3-pyridyl)-1,3-thiazole. To the solution was added under ice-cooling 580 mg of ethoxycarbonylacetylchloride. The mixture was stirred for 30 minutes, to which was then added a saturated aqueous solution of sodium hydrogen chloride. The resultant was subjected to extraction with ethyl acetate. The organic layer was washed with water, dried and concentrated, followed by recrystallization from tetrahydrofuran to give 850 mg (61%) of 2-ethoxycarbonylacetylamino-4-(4-methoxyphenyl)-5-(3-pyridyl)-1,3-thiazole, m.p. 202°-203° C.

出典