反応 #9329

反応方程式

cyclobutanone

n-Butyllithium

1,4-dibromobenzene

→

3-1

収率 54.0%

1-(4-Bromo-phenyl)-cyclobutanol

収率 54.0%

溶媒

THF

THF

反応条件

後処理

1. 1
   洗浄rinsing with 0.5 mL THF
2. 2
   workup.ADDITIONsaturated NH4Cl solution was added
3. 3
   抽出The resulting mixture was extracted with ethyl acetate (3×30 mL)
4. 4
   洗浄the combined ethyl acetate solution was washed with brine
5. 5
   乾燥The solution was then dried (Na2SO4)
6. 6
   ろ過filtered
7. 7
   その他evaporated
8. 8
   その他Purification by flash chromatography on silica gel (5%→10% ethyl acetate/hexanes)

実験手順

n-Butyllithium (1.2 mL 1.92 mmol, 1.6 M/hexanes) was added to a −78° C. solution of 1,4-dibromobenzene (489 mg, 2.07 mmol) in THF (4.2 mL). After 30 min., a solution of cyclobutanone (141 mg, 2.01 mmol) in 1 mL THF was added by cannula, rinsing with 0.5 mL THF. The reaction was allowed to warm to room temperature and after 2 h, saturated NH4Cl solution was added. The resulting mixture was extracted with ethyl acetate (3×30 mL) and the combined ethyl acetate solution was washed with brine. The solution was then dried (Na2SO4), filtered and evaporated. Purification by flash chromatography on silica gel (5%→10% ethyl acetate/hexanes) gave 3-1 (235 mg, 54%).

出典