反応 #93196

反応方程式

3-(2,2-dibromovinyl)-benzaldehyde

KCN

3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid chloride

→

3-(2,2-Dibromovinyl)-α-cyanobenzyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate

溶媒

ether

water

反応条件

後処理

1. 1
   workup.ADDITIONthorough mixing
2. 2
   その他The phases are separated
3. 3
   抽出the aqueous phase is extracted twice
4. 4
   洗浄The ether solution is washed with sodium bisulfite, NaHCO3 and water
5. 5
   乾燥dried over Na2SO4
6. 6
   その他evaporated down

実験手順

In a two-phase reaction mixture, 6.1 g (0.021 mole) of 3-(2,2-dibromovinyl)-benzaldehyde in 50 ml of ether, 1.5 g (0.023 mole) of KCN in 20 ml of water, 5.0 g (0.022 mole) of 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid chloride and 0.5 g of triethylbenzylammonium chloride are stirred at room temperature, and thorough mixing is continued overnight at 25° C. The phases are separated and the aqueous phase is extracted twice by shaking with ether. The ether solution is washed with sodium bisulfite, NaHCO3 and water, dried over Na2SO4 and evaporated down.

出典