反応 #9307

反応方程式

N-[7-(2,4-dichlorophenyl)-2-methylthiopyrazolo[1,5-a]pyridin-3-yl]-N-propylamine

propionaldehyde

sulfuric acid

sodium borohydride

→

title compound

N-[7-(2,4-Dichlorophenyl)-2-methylthiopyrazolo[1,5-a]pyridin-3-yl]-N,N-dipropylamine

溶媒

diethyl ether

Water

tetrahydrofuran

反応条件

後処理

1. 1
   workup.ADDITIONwas added in five portions
2. 2
   workup.STIRRINGstirring
3. 3
   洗浄the extract was washed with saturated aqueous sodium hydrogencarbonate and brine
4. 4
   乾燥After drying over anhydrous magnesium sulfate and filtration
5. 5
   濃縮the solvent was concentrated under reduced pressure
6. 6
   その他the residue was purified by silica gel column chromatography

実験手順

N-[7-(2,4-dichlorophenyl)-2-methylthiopyrazolo[1,5-a]pyridin-3-yl]-N-propylamine (59 mg) was dissolved in tetrahydrofuran (1 mL), and after adding propionaldehyde (0.035 mL) and 3 M aqueous sulfuric acid (0.16 mL), sodium borohydride (12 mg) was added in five portions while vigorously stirring on ice, and stirring was continued for 30 minutes. Water was added to the reaction mixture, extraction was performed with diethyl ether and the extract was washed with saturated aqueous sodium hydrogencarbonate and brine. After drying over anhydrous magnesium sulfate and filtration, the solvent was concentrated under reduced pressure, the residue was purified by silica gel column chromatography, and the title compound (49 mg) was obtained from the n-hexane:ethyl acetate (100:1) fraction as a yellow oil.

出典